While NNH provides valuable information, it has some limitations:
Population Specificity: NNH is specific to the population studied and may not be generalizable to other groups. Event Rate Variability: The calculation is sensitive to the event rates in the study, which can vary across different settings and populations. Does Not Account for Severity: NNH only indicates the number of cases required to see one harm, but it does not account for the severity of the harmful event.
