False Positives: One of the main limitations of FOBT is the potential for false-positive results, which can occur due to other sources of gastrointestinal bleeding, such as from hemorrhoids or dietary factors.
False Negatives: Conversely, FOBT may also yield false-negative results, particularly if the bleeding is intermittent or if the cancer is not bleeding at the time of the test.
Compliance: Although FOBT is less invasive than other screening methods, some individuals may still be reluctant to participate due to the nature of stool sample collection.
