Despite their advantages, case series have notable limitations: - Lack of Control Group: They do not include a control group, which limits the ability to draw causal inferences. - Bias: They are prone to selection bias, as the cases included may not be representative of the broader population. - Confounding Variables: They often cannot account for potential confounding variables that may influence the outcomes. - Limited Generalizability: The findings from a case series may not be generalizable to larger, more diverse populations.
