Renal dysfunction can be caused by various factors including: - Diabetes Mellitus: A leading cause of CKD, uncontrolled blood sugar levels can damage the kidneys over time. - Hypertension: High blood pressure can damage the blood vessels in the kidneys, impairing their ability to function. - Glomerulonephritis: Inflammation of the kidney's filtering units can lead to chronic damage. - Polycystic Kidney Disease: A genetic condition causing multiple cysts in the kidneys, increasing the risk of renal failure. - Acute Kidney Injury (AKI): A sudden loss of kidney function due to factors like severe infection, dehydration, or medication toxicity.