Despite its importance, temperature control faces several challenges. Climate change is a major factor, as it alters temperature patterns and creates new habitats for vectors, expanding the geographical range of diseases. Additionally, socio-economic factors can limit access to technologies like air conditioning, particularly in low-resource settings. Furthermore, the interplay between temperature and other environmental factors complicates the predictability of disease patterns. For instance, humidity and precipitation also influence disease transmission, making comprehensive environmental control necessary.