Globalization: The international nature of food supply chains makes it difficult to monitor and regulate food safety across borders. Antibiotic Resistance: Overuse of antibiotics in agriculture can lead to resistant strains of bacteria, complicating treatment of foodborne illnesses. Emerging Pathogens: New pathogens can emerge, requiring continual adaptation of surveillance and control methods. Resource Limitations: Developing countries may lack the resources and infrastructure for effective food safety measures.