Despite the effectiveness of ART, several challenges remain: 1. Adherence: Patients must adhere strictly to their medication regimen to prevent drug resistance. 2. Drug Resistance: Improper use of ART can lead to the development of drug-resistant HIV strains. 3. Access to Medication: In many low- and middle-income countries, access to ART is limited due to cost and infrastructure issues. 4. Side Effects: Long-term use of ART can lead to side effects such as cardiovascular diseases, liver dysfunction, and metabolic disorders.