What are Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs)?

Non-nucleoside reverse transcriptase inhibitors (NNRTIs) are a class of antiretroviral drugs used primarily to treat HIV/AIDS. NNRTIs work by inhibiting the action of reverse transcriptase, an enzyme critical for the replication of HIV. Unlike nucleoside reverse transcriptase inhibitors (NRTIs), which mimic the natural nucleotides, NNRTIs bind to a different site on the enzyme, causing a conformational change that inhibits its activity.