Diagnosis of Zika virus infection is based on a combination of recent travel history, symptoms, and laboratory tests. Reverse transcription-polymerase chain reaction (RT-PCR) is the primary method used to detect Zika virus RNA in blood, urine, or other body fluids. Serological tests can also be employed to detect Zika virus antibodies, though they may cross-react with other flaviviruses such as dengue.
