Measuring the economic burden involves several methodologies, including cost-of-illness (COI) studies, which calculate the total costs associated with a particular disease. Health economists and epidemiologists use data from healthcare records, surveys, and national databases to estimate these costs. The Disability-Adjusted Life Year (DALY) and Quality-Adjusted Life Year (QALY) metrics are also used to provide a more comprehensive understanding of the burden by incorporating both morbidity and mortality.