TDM involves several steps: 1. Sampling: Blood samples are collected at specific times relative to drug administration. 2. Measurement: Drug concentrations in the blood are measured using techniques such as high-performance liquid chromatography (HPLC) or mass spectrometry. 3. Interpretation: The results are compared against established therapeutic ranges. 4. Adjustment: Based on the results, healthcare providers may adjust the dosing regimen to maintain optimal drug levels.