How is Hydroxyurea Used in Treating Sickle Cell Disease?
In the context of sickle cell disease, hydroxyurea has been shown to increase fetal hemoglobin (HbF) production, which helps in reducing the formation of sickle-shaped red blood cells. Clinical trials and observational studies have demonstrated that hydroxyurea reduces the frequency of vaso-occlusive crises, acute chest syndrome, and the need for blood transfusions in patients with sickle cell disease.
