Treatment for H1N1 influenza typically involves antiviral medications such as oseltamivir (Tamiflu) and zanamivir (Relenza). These antivirals are most effective when administered within 48 hours of symptom onset. Supportive care, including rest, hydration, and over-the-counter medications to relieve symptoms, is also important. In severe cases, hospitalization may be required for supplemental oxygen or mechanical ventilation.