Several metrics are used to quantify disease burden, the most common of which are Disability-Adjusted Life Years (DALYs) and Quality-Adjusted Life Years (QALYs). DALYs combine the years of life lost due to premature mortality and the years lived with disability, providing a comprehensive measure of overall burden. QALYs, on the other hand, assess the quality of life and are often used in cost-effectiveness analyses of healthcare interventions.