Variability in drug response arises due to several factors, including:
Genetic Factors: Genetic polymorphisms can influence drug metabolism and efficacy. Environmental Factors: Diet, lifestyle, and concomitant drug use can alter drug response. Physiological Factors: Age, sex, and organ function (e.g., liver and kidney) affect how drugs are processed in the body. Disease States: Comorbidities can impact drug absorption, distribution, metabolism, and excretion.
