How Does Pathogen Dose Affect Transmission Dynamics?

Pathogen dose plays a significant role in the transmission dynamics of infectious diseases:
1. Basic Reproduction Number (R0): The dose can influence the basic reproduction number, which represents the average number of secondary infections generated by one infected individual.
2. Super-Spreading Events: High doses can lead to super-spreading events, where one individual infects a disproportionately large number of others.
3. Herd Immunity: Understanding dose-response relationships can help in achieving herd immunity through vaccination and other control measures.