How does GRADE determine the strength of recommendations?
The strength of recommendations is categorized as either strong or weak. This determination is based on:
Quality of Evidence: Higher quality evidence usually supports stronger recommendations. Balance of Benefits and Harms: If the benefits greatly outweigh the harms, the recommendation is likely to be strong. Values and Preferences: Considering how different individuals value the outcomes can influence the strength of recommendations. Resource Use: The cost and resource implications of an intervention also play a role in determining the strength.
