How Does Differential Misclassification Affect Study Results?
The primary concern with differential misclassification is that it can either exaggerate or underestimate the association between exposure and outcome. For example, if cases are more likely to recall past exposures than controls, it can lead to an overestimation of the association in case-control studies. Conversely, if there is a systematic error that leads to underreporting of exposures in a specific group, it may underestimate the true association.