Clomiphene citrate works by inducing the release of gonadotropins—hormones that stimulate the ovaries. It does this by blocking estrogen receptors in the hypothalamus, a part of the brain that plays a critical role in hormone regulation. This blockade leads to an increase in the secretion of follicle-stimulating hormone (FSH) and luteinizing hormone (LH), which in turn stimulates the ovaries to produce and release eggs.
