The criteria involve a combination of personal and family medical history. Key components include:
A diagnosis of sarcoma, brain tumor, or adrenocortical carcinoma before the age of 45. A first-degree relative diagnosed with any cancer before the age of 45. A second-degree relative with any cancer diagnosed before the age of 60.
If an individual meets these criteria, genetic testing for the TP53 mutation is recommended. Positive identification of this mutation has significant implications for surveillance and management.
