How do BRCA1 and BRCA2 Mutations Affect Cancer Risk?
Mutations in BRCA1 and BRCA2 significantly increase the risk of developing breast and ovarian cancer. Women with a BRCA1 mutation have a 55-65% chance of developing breast cancer by age 70, while those with a BRCA2 mutation have a 45% chance. The risk for ovarian cancer is also elevated, with BRCA1 mutations carrying a 39% risk and BRCA2 mutations a 17% risk.
