The incidence of GI bleeding varies by population and setting. It is a common cause of hospital admissions, especially among the elderly. In the United States, upper gastrointestinal bleeding (UGIB) occurs in approximately 100-200 per 100,000 adults annually. Lower gastrointestinal bleeding (LGIB) is less common, with an incidence of about 20-27 per 100,000 adults each year.