Transmission of TSEs varies by type and species. In humans, some TSEs like Kuru are transmitted through ritualistic cannibalism, while others like variant CJD (vCJD) are linked to the consumption of contaminated beef. In animals, BSE is thought to spread through feed containing infected animal products, and CWD can spread through direct contact or environmental contamination. The prions are remarkably resistant to standard decontamination methods, complicating control efforts.