Incidence Rate: Incidence Rate = (Number of New Cases / Population at Risk) x 100,000 Prevalence Rate: Prevalence Rate = (Total Number of Cases / Total Population) x 100,000 Mortality Rate: Mortality Rate = (Number of Deaths / Population) x 100,000 Case Fatality Rate: Case Fatality Rate = (Number of Deaths from Disease / Number of Diagnosed Cases) x 100 Reproductive Number (R0): This is often estimated using complex mathematical models.