While neutralizing antibodies are a powerful defense mechanism, they are not without limitations:
Viral Mutations: Pathogens can mutate, potentially evading detection by pre-existing neutralizing antibodies. Antibody-dependent Enhancement: In rare cases, antibodies can enhance viral entry into cells, worsening the infection. Limited Breadth: Some neutralizing antibodies target specific epitopes, making them less effective against different strains of the same pathogen.