Yes, there are numerous examples where interventions showed no indication of clinical usefulness:
- Screening Tests: Certain cancer screening tests, such as prostate-specific antigen (PSA) testing for prostate cancer, have been controversial. Studies have shown that PSA testing does not significantly reduce mortality rates and may lead to overdiagnosis and overtreatment. - Medications: Some medications, like certain antidepressants for mild depression, have not shown significant benefits compared to placebos in clinical trials. - Surgical Procedures: Some surgical interventions, such as arthroscopic surgery for osteoarthritis of the knee, have been found to offer no significant benefit over conservative treatments like exercise and physical therapy.
