Systolic Hypertension in the Elderly Program (shep) - Epidemiology

Introduction to Systolic Hypertension in the Elderly Program (SHEP)

The Systolic Hypertension in the Elderly Program (SHEP) was a landmark clinical trial aimed at understanding the effects of treating isolated systolic hypertension in older adults. This condition, characterized by elevated systolic blood pressure (≥160 mm Hg) with normal diastolic pressure (

Relevant Publications

How We Got Where We Are in Blood Pressure Targets.

Issue Release: 2021

Association of orthostatic hypertension with mortality in the Systolic Hypertension in the Elderly Program.

Issue Release: 2019

Timeline of History of Hypertension Treatment.

Issue Release: 2016

Functional Status and Antihypertensive Therapy in Older Adults: A New Perspective on Old Data.

Issue Release: 2015

Rapid decreases in blood pressure from antihypertensive treatment were associated with increased cancer mortality in the Systolic Hypertension in the Elderly Program.

Issue Release: 2014

Competing cardiovascular and noncardiovascular risks and longevity in the systolic hypertension in the elderly program.

Issue Release: 2013

Association between chlorthalidone treatment of systolic hypertension and long-term survival.

Issue Release: 2011

Effects of antihypertensive drug treatment on the risk of dementia and cognitive impairment.

Issue Release: 2008

Long-term fatal outcomes in subjects with stroke or transient ischemic attack: fourteen-year follow-up of the systolic hypertension in the elderly program.

Issue Release: 2008

Simulation of the Syst-Eur randomized control trial using a primary care electronic medical record was feasible.

Issue Release: 2006

A cost-minimization analysis of diuretic-based antihypertensive therapy reducing cardiovascular events in older adults with isolated systolic hypertension.

Issue Release: 2005

Lipoprotein levels are associated with incident hypertension in older adults.

Issue Release: 2004

Effect of antihypertensive agents on quality of life in the elderly.

Issue Release: 2004

Trials in isolated systolic hypertension: an update.

Issue Release: 2003

Blood pressure and decline in kidney function: findings from the Systolic Hypertension in the Elderly Program (SHEP).

Issue Release: 2002

Isolated systolic hypertension: a new challenge in medicine.

Issue Release: 2002

Depression and risk of heart failure among older persons with isolated systolic hypertension.

Issue Release: 2001

Benefits of antihypertensive drug treatment in elderly patients with isolated systolic hypertension.

Issue Release: 2001

Association of increased pulse pressure with the development of heart failure in SHEP. Systolic Hypertension in the Elderly (SHEP) Cooperative Research Group.

Issue Release: 2001

Dementia and disability outcomes in large hypertension trials: lessons learned from the systolic hypertension in the elderly program (SHEP) trial.

Issue Release: 2001

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