Measuring QoL presents several challenges: 1. Subjectivity: QoL is inherently subjective, making it difficult to capture accurately and consistently across different individuals and cultures. 2. Complexity: It involves multiple dimensions that are interrelated, complicating the measurement and interpretation of results. 3. Response Bias: Participants may respond differently based on their mood, current health status, or social desirability, affecting the reliability of the data.