How Do Species Differences Influence Vaccine Development?
Species differences play a significant role in vaccine development and effectiveness. Vaccines developed for one species may not be effective in another due to differences in immune system responses. For example, the development of the rabies vaccine required understanding the disease's pathogenesis in different species, including humans, dogs, and wildlife.
Species-specific factors also influence the choice of animal models in preclinical trials. Researchers must select appropriate animal models that closely mimic the human disease to evaluate the safety and efficacy of potential vaccines.
