How Do Endogenous Antigens Trigger an Immune Response?

The immune system's ability to recognize and respond to endogenous antigens is crucial for maintaining health. When cells are infected by pathogens or become malignant, they present fragments of these endogenous antigens on their surface using molecules called major histocompatibility complex (MHC) class I. This presentation is recognized by cytotoxic T cells, which can then target and destroy the compromised cells. This process is essential in controlling infections and preventing the development of cancer.